The IITC Life Science the original Electronic von Frey Aestehsiometeris used to assess mechanical allodynia with rigid tips (threshold) and the “Supertips™” (flexible von Frey hairs) are used for sensory test on all test subjects from all animal test subjects and human studies.

The 2390 series enables researchers to use up to 5 total test disciplines wath a single unit. Multiple users have the ability to use one single unit for multiple studies.

Our system is the first system introduced to the market over 11 years ago which finally allows researchers the ability to test and automatically record pain threshold values in a clean, accurate easy to use compact system.

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The systems are supplied with either a 90, 800 or 1000 gram probe. Probe type is determined by test subject.

When studies call for pain threshold, rigid tips are used when measuring sensory threshold one of the 15 Supertips™ are used. The IITC hairs are unique in design - each hair has a uniform tip of .8mm in diameter, eliminating the possibility of false readings that may occur due to the varying hair thickness when applied to test subject.

The systems will allow you to measure, store and display your test readings in grams based upon the amount of pressure applied. Manually calculating results is no longer required with the IITC system.

Testing is simple, choose one of the supplied tips place on probe tip; apply pressure probe to test subject, upon reaction the unit will display and store your reading in grams, an easy, quick test system for all pain studies.

An internal load cell is attached to the small tip, this is the central element in the system; which connected to the electronic system allows you digitally record your test results.

All EVF systems are calibrated at the factory and do not require any type of constant calibration, adjustment or separate calibrator to be purchased.

The optional analog output cable supplies a pressure analog output voltage (mV range) exactly proportional to the applied pressure. The signal is free floating and can be used on both chart recorders and/or AD converters.

Our system is an easy, user friendly system which was developed to replace the traditional hairs but at the same time enabling researchers to not only test sensory but pain threshold in one system.

Features
MRI Probe available
Plug up to 3 probes into a single unit
LCD Readout (Floating or last max. & minimum)
Rigid tips up to 800 Gr.
“Supertips™” 15 up to 65 Gr.
1K probe available
Microprocessor Electronics 0.1 Gr Plug-in probes
Independence from Hygroscopy
Independence from temperature
Optional analog output cable
Pipette tips can be customized to any specification
Hygroscopy is no longer an issue.

What are “Supertips™”

As reported by earlier papers varying probe diameter on von Frey hairs is a serious problem. These patented “Supertips™” have a UNIFORM TIP DIAMETER OF .8mm ON ALL 15 DIFFERENT VON FREY HAIRS! This is a unique feature available only on Electronic von Freys by IITC Inc. Probe size no longer affects pain or pressure thresholds and results are finally comparable! All tips can be ordered individually.

This instrument eliminates the poor data collection due to the hygroscopic nature of von Frey hairs (it is proven that relative humidity can change the force by more than 100% between 28-52% relative humidity change!) Only an accurate readout can show the actual force, not a number as on the handle of classic von Frey handles. Bending at various degrees can change the force by 20-30% in every case, this is visible with an electronic readout only. The natural limiting of force with flexible hairs is of great advantage. This instrument makes the up-down method of finding threshold unnecessary. Without using line adapter, Battery life is 50 hours. (Supplied)

One year warranty
120/240V
CE

Part #	Description
2390	Electronic von Frey rigid tips only included, 90 gram range
2391	Electronic von Frey rigid tips only included, 800 gram range
2392	Electronic von Frey rigid and 15 Supertips included, 90 gram range
2393	Electronic von Frey rigid and 15 Supertips included, 800 gram range
23931	Electronic von Frey custom rigid tips only included, 1000 gram range
2394	Probe only, 90 gram range
2395	Probe only, 800 gram range
2396	Probe only, 1000 gram range
2397	MRI Probe
2398	Limit indicator for any probe
2399	Cable for limit indicator
2400	Analog output cable

 

Literature Reference:

1. Effects on Birth Weight and Adult Health in Rats Prenatally Exposed to Toxicants or Undernutrition.
Brain E. Grey, Brenda Barbee, Kaberi Das, Joel Norwood, Christopher Lau, and John M. Rogers.
Reproductive Toxicology Division, NHEERL, ORD, U.S. Environmental Protection Agency, Research Triangle Park, NC
Poster Presented at SOT 2007

2. Deep tissue inflammation upregulates neuropeptides and evokes nociceptive behaviors which are modulated by a neuropeptide antagonist
Ranjinidevi Ambalavanar, Masayuki Moritani, Aicha Moutanni, Panduranga Gangula, Chandrasekha Yallampalli, Dean Dessem
Pain 120 (2007) 53-68

3. Evaluation of a von Frey Device for Pharmacoddynamic Modeling of Morphine in Dogs.
Butch KuKanich, B. Duncan X. Lascelles, Mark G. Papich
Comparatrive Pain and Pharmacology Research Laboratories

4. An electronic pressure-meter nociception paw test for rats
G.G. Vivancos, W.A. Verri Jr, T.M. Cunha, I.R.S. Schivo, C.A. Parada,
F.Q. Cunha and S.H. Ferreira
Brazilian Journal of Medical and Biological Research (2004) 37:391-399

5. An electronic pressure-meter nociception paw test for rats
G.G. Vivancos, W.A. Verri Jr, T.M. Cunha, I.R.S. Schivo, C.A. Parada,
F.Q. Cunha and S.H. Ferreira
Brazilian Journal of Medical and Biological Research (2004) 37:401-407

6. Assessment of von Frey device for evalution of the antinociceptive effects of morphine and its application in pharmacodynamic modeling of morphine in dogs
Butch KuKanich, DVM, PhD; B. Duncan X. Lascelles, BVSc, PhD; Mark G. Papich, DVM, MS
American journal of Veterinary Research 2005 66(9).

7. Cairns BE, Gambarota G, Svensson P, Arendt-Nielsen L, Berde CB. Glutamate-induced sensitization of rat masseter muscle fibers. Neuroscience, 2002; 109: 389-399.

8. Arpad Dobolyi, Hiroshi Ueda, Hitoshi Uchida, Miklos Palkovits, and Ted B. Usdin, Anatomical and physiological evidence for involvement of tuberoinfundibular peptide of 39 residues in nociception. , , PNAS, February 5, 2002, volume. 99, no. 3, 1651 to 1656

9. Jensen K. Andersen et al: Pressure-Pain threshold In Human Temporal Region. Evaluation of A New Pressure Algometer Pain, 1986;25:313-23. (This is why"SupertipsTM" exist!) Poster at IASP Congress San Diego 2002

10. 437-P71 Performance of Von frey polyamide Monofilaments During Changes in relative Humidity: A Calibration Study. Per R. Neilsen, Mads U. Werner, Catarina Ellehuus. Dept Anesthesiology, Univ Hospital, Hvidovre, Denmark (spon: Per R. Nielsen)

11. Assessment of Stimulation Parameters Used In Measuring Mechanical Hyperalgesia In Animal Models Of Pain. Harry J. Gould, III, R. Denis Soignier, Porter Nolan, Sarah J. Vitale, and Dennis Paul. Departments of Neurology and Pharmacology, and Neuroscience Center of Excellence LSU Health Sciences Center, New Orleans, LA, USA 70112

12. Abstract: Validation of an Electronic Von Frey Device in a Rat Model of Incisional Pain and its use in Assessing the Efficacy of Clinically Relevant Analgescis. L. Mark; G. Whiteside, J. Boulet, K. Walker., Discovery Research, Purdue Pharma, Cranbury, NJ, USA (presented at SFN 2003)